Yi-Chung Tung 董奕鍾
Associate Research Fellow

Ways to contact me:

Phone: 886-2-2787-3138 (Office) 886-2-2787-3162 (Lab)
Fax: 886-2-2787-3122
Address: Research Center for Applied Sciences, Academia Sinica
128 Sec. 2, Academia Rd., Nankang, Taipei 11529, Taiwan



Research Fields:

  • Integrated Biomedical Microdevices, Cell Culture in Various Micro-Environments, Micro/Nanofluidics, Polymer/Silicon Hybrid Microsystems, Advanced Micro/Nano Fabrication Techniques.

Recent Publications:

  1. H.-J. Chiang, S.-L. Yeh, C.-C. Peng, W.-H. Liao, and Y.-C. Tung*, “Polydimethylsiloxane-Polycarbonate Microfluidic Devices for Cell Migration Studies under Perpendicular Chemical and Oxygen Gradients,” Journal of Visualized Experiments, in press.
  2. C.-H. Lin, C.-K. Wang, Y.-A. Chen, C.-C. Peng, W.-H. Liao, and Y.-C. Tung*, “Measurement of In-Plane Elasticity of Live Cell Layers Using a Pressure Sensor Embedded Microfluidic Device,” Scientific Reports, Vol. 6, 36425 (14 pages), November 2016.
    [ DOI:10.1038/srep36425 ]
  3. S.-C. Lin, Y.-L. Sung, C.-C. Peng, Y.-C. Tung*, and C.-T. Lin*, “An In-Situ Filtering Pump for Particle-Sample Filtration Based on Low-Voltage Electrokinetic Mechanism,” Sensors and Actuators B: Chemical, Vol. 238, pp. 809-816, January 2017.
    [ DOI:10.1016/j.snb.2016.07.147 ]
  4. S.-C. Lin, Y.-C. Tung*, and C.-T. Lin*, “A Frequency-Control Particle Separation Device Based on Resultant Effects of Electroosmosis and Dielectricphoresis,” Appl. Phys. Lett., Vol. 109, Issue 5, 053701 (5 pages), 2016.
    [ DOI:10.1063/1.4960359 ]
  5. B. Patra, C.-C. Peng, W.-H. Liao, C.-H. Lee, and Y.-C. Tung*, “Drug Testing and Flow Cytometry Analysis on a Large Number of Uniform Sized Tumor Spheroids Using a Microfluidic Device,” Scientific Reports, Vol. 6, 21061 (12 pages), February 2016.
    [ DOI:10.1038/srep21061 ]
  6. C.-W. Chang, C.-C. Peng, W.-H. Liao, and Y.-C. Tung*, “Polydimethylsiloxane SlipChip for Mammalian Cell Culture Applications,” Analyst, Vol. 140, Issue 21, pp. 7355-7365, October 2015.
    [ DOI:10.1039/c5an00547g ]
  7. Y.-H. Chen, C.-C Peng, and Y.-C. Tung*, “Flip Channel: Uniform-Sized Embryoid Body Formation and Differentiation in a Microfluidic Device,” Biomicrofluidics, Vol. 9, Issue 5, 054111 (11 pages), September 2015.
    [ DOI:10.1063/1.4931638 ]
  8. Y.-F. Hsiao, H.-J. Pan, Y.-C. Tung, C.-C. Chen*, and C.-H. Lee*, “Effects of Hydraulic Pressure on Cardiomyoblasts in a Microfluidic Device,” Biomicrofluidics, Vol. 9, Issue 2, pp. 024111 (10 pages), March 2015.
    [ DOI:10.1063/1.4917080 ]
  9. P.-L. Ko, F.-L. Chang, C.-H. Li, J.-Z. Chen*, I.-C. Cheng, Y.-C. Tung, S.-H. Chang, and P.-C. Lin*, "Dynamically Programmable Surface Micro-Wrinkles on PDMS-SMA Composite," Smart Materials and Structures, Vol. 23, No. 11, pp. 115007 (9 pages), November 2014.
    [ DOI:10.1088/0964-1726/23/11/115007 ]
  10. C.-W. Chang, Y.-J. Cheng, M. Tu, Y.-H. Chen, C.-C. Peng, W.-H. Liao, and Y.-C. Tung*, "Polydimethylsiloxane-polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies," Lab Chip, Vol. 14, Issue 19, pp. 372-3772, September 2014.
    [ DOI:10.1039/C4LC00732H ]
  11. B. Patra, Y.-S. Peng, C.-C. Peng, W.-H. Liao, Y.-A. Chen, K.-H. Lin, Y.-C. Tung*, C.-H. Lee*, “Migration and Vascular Formation of Endothelial Cells in Cancer Cell Spheroids of Various Sizes,” Biomicrofluidics, Vol. 8, pp. 052109 (10 pages), September 2014.
    [ DOI:10.1063/1.4895568 ]
  12. T.-Y. Ling*, Y.-L Liu, Y.-K. Huang, S.-Y. Gu, H.-K. Chen, C.-C. Ho, P.-N. Tsao, Y.-C. Tung, H.-W. Chen, C.-H. Cheng, K.-H. Lin, F.-H. Lin “Differentiation of Lung Stem/Progenitor Cells into Alveolar Pneumocytes and Induction of Angiogenesis within a 3D Gelatine Microbubble Scaffold,” Biomaterials, Vol. 35, Issue 22, pp. 5660-5669, July 2014.
    [ DOI:10.1016/j.biomaterials.2014.03.074 ]
  13. Y.-H. Chen, C.-C Peng, Y.-J. Cheng, J.-G. Wu, and Y.-C. Tung*, “Generation of Nitric Oxide (NO) Gradients in Microfluidic Devices for Cell Culture Using Spatially Controlled Chemical Reactions,” Biomicrofluidics, Vol. 7, Issue 6, pp. 064104 (10 pages), November 2013.
    [ DOI:10.1063/1.4829775 ]
  14. B. Patra, Y.-H. Chen, C.-C. Peng, S.-C. Lin, C.-H. Lee*, and Y.-C. Tung*, “A Microfluidic Device for Uniform-Sized Cell Spheroids Formation, Culture, Harvesting and Flow Cytometry Analysis,” Biomicrofluidics, Vol. 7, Issue 5, pp. 054114 (11 pages), 2013.
    [ DOI:10.1063/1.4824480 ]
  15. C.-C. Peng, W.-H. Liao, Y.-H. Chen, C.-Y. Wu, and Y.-C. Tung*, “A Microfluidic Cell Culture Array with Various Oxygen Tensions,” Lab Chip, Vol. 13, Issue 16, pp. 3239-3245, August 2013.
    [ DOI:10.1039/C3LC50388G ]
  16. S.-C. Lin, J.-C. Lu, Y.-L. Sung, C.-T. Lin*, and Y.-C. Tung*, “A Low Sample Volume Particle Separation Device with Electrokinetic Pumping Based on Circular Traveling-Wave Electroosmosis,” Lab Chip, Vol. 13, Issue 15, pp. 3082-3089, August 2013.
    [ DOI:10.1039/C3LC50343G ]
  17. M.-C. Liu, S.-C. Shih, J.-G. Wu, T.-W. Weng, C.-Y. Wu, J.-C. Lu, and Y.-C. Tung*, “Electrofluidic pressure sensor embedded microfluidic device: a study of endothelial cells under hydrostatic pressure and shear stress combinations,” Lab Chip, Vol. 13, Issue 9, pp. 1743-1753, May 2013.
    [ DOI:10.1039/C3LC41414K ]
  18. J.-W. Huang, H.-J. Pan, W.-Y. Yao, Y.-W. Tsao, W.-Y. Liao, C.-W. Wu, Y.-C. Tung*, and C.-H. Lee*, “Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain,” Lab Chip, Vol. 13, Issue 6, pp. 1114-1120, March 2013.
    [ DOI:10.1039/C2LC41050H ]
  19. Z.-H. Yang, F.-C. Chien, C.-W. Kuo, D.-Y. Chueh, Y.-C. Tung, and P. Chen*, “Interfacial adhesion and superhydrophobicity modulated with polymeric nanopillars using integrated nanolithography,” J. Micromech. Microeng., Vol. 22, No. 12, pp. 125026-125036, December 2012.
    [ DOI:10.1088/0960-1317/22/12/125026 ]
  20. C.-Y. Wu, J.-C. Lu, M.-C. Liu, and Y.-C. Tung*, “Integrated Electrofluidic Circuits: Pressure Sensing with Analog and Digital Functionalities for Microfluidics” Lab Chip, Vol. 12, Issue 20, pp. 3943-3951, October 2012. (published as part of a themed issue dedicated to Emerging Investigators)
    [ DOI:10.1039/C2LC40436B ]
  21. Y.-C. Tung, N.-T. Huang, B.-R. Oh, B. Patra, C.-C. Pan, T. Qiu, P. K. Chu, W. Zhang*, and K. Kurabayashi*, “Optofluidic Detection for Cellular Phenotyping,” Lab Chip, Vol. 12, Issue 19, pp. 3552-3565, October 2012. (featured as the front cover image)
    [ DOI:10.1039/C2LC40509A ]
  22. S.-C. Lin, P.-W. Yen, C.-C. Peng, and Y.-C. Tung*, “Single Channel Layer, Single Sheath-Flow Inlet Microfluidic Flow Cytometer with Three-Dimensional Hydrodynamic Focusing,” Lab Chip, Vol. 12, Issue 17, pp. 3135-3141, September 2012.
    [ DOI:10.1039/C2LC40246G ]
  23. J.-C. Lu, W.-H. Liao, and Y.-C. Tung*, “Magnet-Assisted Device-Level Alignment for Fabrication of Membrane-Sandwiched Polydimethylisiloxane (PDMS) Microfluidic Devices,” J. Microme. Microeng., Vol. 22, No. 7, pp. 75006-75013, July 2012.
    [ DOI:10.1088/0960-1317/22/7/075006 ]
  24. A. Y. Hsiao, Y.-C. Tung, X. Qu, L. R. Patel, K. J. Pienta, and S. Takayama*, “384 Hanging Drop Arrays Give Excellent Z-factors and Allow Versatile Formation of Co-culture Spheroids,” Biotechnol. Bioeng, Vol. 109, pp. 1293-1304, May 2012.
    [ DOI:10.1002/bit.24399 ]
  25. A. Y. Hsiao, Y.-C. Tung, C.-H. Kuo, B. Mosadegh, R. Bedenis, K. J. Pienta, and S. Takayama*, "Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates," Biomed. Microdevices, Vol. 12, pp. 313-323, April 2012.
    [ DOI:10.1007/s10544-011-9608-5 ]
  26. M.-C. Liu, J.-G. Wu, M.-F. Tsai, W.-S. Yu, P.-C. Lin*, I.-C. Chiu, H.-A. Chin, I.-C. Cheng, Y.-C. Tung, and J. Z. Chen*, “Two Dimensional Thermoelectric Platforms for Thermocapillary Droplet Actuation,” RSC Advances, Vol. 2, pp. 1639-1642, February 2012.
    [ DOI:10.1039/C1RA00896J ]
  27. Y.-A. Chen, A. D. King, H.-C. Shih, C.-C. Peng, C.-Y. Wu, W.-H. Liao, and Y.-C. Tung*, "Generation of Oxygen Gradients in Microfluidic Devices for Cell Culture Using Spatially Confined Chemical Reactions," Lab Chip, Vol. 11, pp. 3626-3633, October 2011.
    [ DOI:10.1039/C1LC20325H ]
  28. C.-Y. Wu, W.-H. Liao, and Y.-C. Tung*, "Integrated Ionic Liquid-Based Electrofluidic Circuits for Pressure Sensing within Polydimethylsiloxane Microfluidic Systems," Lab Chip, Vol. 11, pp. 1740-1746, May 2011 (featured as the back cover image).
    [ DOI:10.1039/C0LC00620C ]
  29. N. J. Douville, P. Zamankhan, Y.-C. Tung, R. Li, B. L. Vaughan, C. F. Tai, J. White, P. J. Christensen, J. B. Grotberg, and S. Takayama*, “Combination of Fluid and Solid Mechanical Stresses Contribute to Cell Death and Detachment in a Microfluidic Alveolar Model,” Lab Chip, Vol. 11, pp. 609-619, February 2011 (featured as the inside cover image).
    [ DOI:10.1039/C0LC00251H ]
  30. Y.-C. Tung, A. Y. Hsiao, S. G.. Allen. Y. Torisawa, M. Ho, and S. Takayama*, “High-Throughput 3D Spheroid Culture and Drug Testing Using a 384 Hanging Drop Array,” Analyst, Vol. 136, pp. 473-478, February 2011 (featured as the cover image).
    [ DOI:10.1039/C0AN00609B ]
  31. N.-T. Huang, S. C. Truxal, Y.-C. Tung, A. Y. Hsiao, G. D. Luker, S. Takayama, and K. Kurabayashi*, “Multiplexed Spectral Signature Detection for Microfluidic Color-Coded Bioparticle Flow,” Anal. Chem., VOl. 82, pp. 9506-9512, November 2010.
    [ DOI:10.1021/ac102240g ]
  32. B. Mosadegh, C.-H. Kuo, Y.-C. Tung, Y. Torisawa, T. Bersano-Begey, H. Tavana, and S. Takayama*, “Integrated Elastomeric Components for Autonomous Regulation of Sequential and Oscillatory Flow Switching in Microfluidic Devices,” Nature Physics, Vol. 6, pp. 433-437, June 2010.
    [ DOI:10.1038/nphys1637 ]
  33. W. Cha, Y.-C. Tung, M. E. Meyerhoff*, and S. Takayama*, “Patterned Electrode-Based Amperometric Gas Sensor for Direct Nitric Oxide Detection within Microfluidic Devices,” Analytical Chemistry, Vol. 82, Issue 8, pp. 3300-3305, April 2010.
    [ DOI:10.1021/ac100085w ]
  34. N. J. Douville, Y.-C. Tung, R. Li, J. D. Wang, M. E. H. El-Sayed, and S. Takayama*, “Fabrication of Two-Layered Channel System with Embedded Electrodes to Measure Resistance across Epithelial and Endothelial Barriers,” Analytical Chemistry, Vol. 82, Issue 6, pp. 2505-2511, March 2010.
    [ DOI:10.1021/ac9029345 ]
  35. N.-T. Huang, S. C. Truxal, Y.-C. Tung, A. Hsiao, S. Takayama, and K. Kurabayashi*, "High-Speed Tuning of Visible Laser Wavelength Using a Nanoimprinted Grating Optical Tunable Filter," Applied Physics Letters, Vol. 95, Issue 21, pp. 21106 (3 pages), November 2009.
    [ DOI:10.1063/1.3267083 ]
  36. J. W. Song, S. P. Cavnar, A. C. Walker, K. E. Luker, M. Gupta, Y.-C. Tung, G. D. Luker, and S. Takayama*, “Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells,” PLoS One, Vol. 4, Issue. 6, pp. e5756 (10 pages), June 2009.
    [ DOI:10.1371/journal.pone.0005756 ]
  37. A. Y. Hsiao, Y. Torisawa, Y.-C. Tung, S. Sud, R. S. Taichman, K. J. Pienta, and S. Takayama*, “Microscale System for Formation of PC-3 Prostate Cancer Co-Culture Spheroids,” Biomaterials, Vol. 30, Issue 16, pp. 3020-3027, June 2009.
    [ DOI:10.1016/j.biomaterials.2009.02.047 ]
  38. G. Mehta, J. Lee, W. Cha, Y.-C. Tung, J. J. Linderman, and S. Takayama*, “Hard Top Soft Bottom Microfluidic Devices for Cell Culture and Chemical Analysis,” Analytical Chemistry, Vol. 81, Issue 10, pp. 3714-3722, May 2009.
    [ DOI:10.1021/ac802178u ]
  39. T. Uchida, K. L. Mills, C.-H. Kuo, W. Roh, Y.-C. Tung, M. D. Thouless, and S. Takayama*, “External Compression-Induced Fracture Patterning on the Surface of Poly(dimethylsiloxane) Cubes and Microspheres,” Langmuir, Vol. 25, No. 5, pp.3102-3107, February 2009.
    [ DOI:10.1021/la801986k ]
  40. S. C. Truxal, K. Kurabayashi*, and Y.-C. Tung, “Design of a MEMS Tunable Polymer Grating for a Single Detector Spectroscopy,” International Journal of Optomechatronics, Vol. 2, Issue 2, pp. 75-87, June 2008.
    [ DOI:10.1080/15599610802081779 ]
  41. Y. Kamotani, T. Bersano-Begey, N. Kato, Y.-C. Tung, D. Huh, J. W. Song, and S. Takayama*, “Individually Programmable Cell Stretching Microwell Arrays Actuated by a Braille Display,” Biomaterials, Vol. 29, Issue 17, pp. 2646-2655, June 2008.
    [ DOI:10.1016/j.biomaterials.2008.02.019 ]
  42. C. Y. Fan, Y.-C. Tung, S. Takayama, E. Meyhöfer*, and K. Kurabayashi*, “Electrically Programmable Surfaces for Configurable Pattering of Cells,” Advanced Materials, Vol. 20, Issue 8, pp. 1418-1423, April 2008.
    [ DOI:10.1002/adma.200702191 ]
  43. S. C. Truxal, Y.-C. Tung, and K. Kurabayashi*, “A Flexible Nanograting Integrated Onto Silicon Micromachines by Soft Lithographic Replica Molding and Assembly,” IEEE/ASME Journal of Microelectromechanical Systems, Vol. 17, No. 2, pp. 393-401, April 2008.
    [ DOI:10.1109/JMEMS.2008.918400 ]
  44. S. C. Truxal, Y.-C. Tung, and K. Kurabayashi*, “High-Speed Deformation Soft Lithographic Nano-Grating Patterns for Ultra Sensitive Optical Spectroscopy,” Applied Physics Letters, Vol. 92, Issue 5, pp. 051116 (3 pages), February 2008 (also published in Virtual Journal of Nanoscale Science and Technology, Vol. 17, No. 8).
    [ DOI:10.1063/1.2842415 ]
  45. D. Huh, H. Fujioka, Y.-C. Tung, N. Futai, R. Paine III, J. B. Grotberg, and S. Takayama*, “Acoustically Detectable Cellular-Level Lung Injury Induced by Fluid Mechanical Stresses in Microfluidic Airway Systems,” Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 48, pp. 18886-18891, November 2007.
    [ DOI:10.1073/pnas.0610868104 ]
  46. Y.-C. Tung, Y. Torisawa, N. Futai, and S. Takayama*, “Small Volume, Low Mechanical Stress Cytometry Using Computer-Controlled Braille Display Microfluidics,” Lab on a Chip, Vol. 7, Issue 11, pp. 1497-1503, November 2007.
    [ DOI:10.1039/B708187A ]
  47. Y. S. Heo, L. M. Cabrera, J. W. Song, N. Futai, Y.-C. Tung, G. D. Smith, and S. Takayama*, “Characterization and Resolution of Evaporation Mediated Osmolality Shifts that Constrain Microfluidic Cell Culture in Poly(dimethylsiloxane) Devices,” Analytical Chemistry, Vol. 79, No. 3, pp. 1126-1134, February 2007.
    [ DOI:10.1021/ac061990v ]
  48. W. Gu, H. Chen, Y.-C. Tung, J-C. D. Meiners, and S. Takayama*, “Multiplexed Hydraulic Valve Actuation Using Ionic Liquid Filled Soft Channels and Braille Displays,” Applied Physics Letters, Vol. 90, Issue. 3, pp. 033505 (3 pages), January 2007 (also published in Virtual Journal of Nanoscale Science and Technology, Vol. 15, No. 4).
    [ DOI:10.1063/1.2431771 ]
  49. Y.-C. Tung* and K. Kurabayashi*, “A Metal-Coated Polymer Micromirror for Strain-Driven High-Speed Multi-Axis Optical Scanning,” IEEE Photonics Technology Letters, Vol. 17, No. 6, pp.1193-1195, June 2005.
    [ DOI:10.1109/LPT.2005.846613 ]
  50. Y.-C. Tung* and K. Kurabayashi*, “A Single-Layer PDMS-on-Silicon Hybrid Micro Actuator with Multi-Axis Out-of-Plane Motion Capabilities, Part I: Design and Analysis,” IEEE/ASME Journal of Microelectromechanical Systems, Vol. 14, No. 3, pp. 548-557, June 2005.
    [ DOI:10.1109/JMEMS.2005.844761 ]
  51. Y.-C. Tung* and K. Kurabayashi*, “A Single-Layer PDMS-on-Silicon Hybrid Micro Actuator with Multi-Axis Out-of-Plane Motion Capabilities, Part II: Fabrication and Characterization,” IEEE/ASME Journal of Microelectromechanical Systems, Vol. 14, No. 3, pp. 558-566, June 2005.
    [ DOI:10.1109/JMEMS.2005.844761 ]
  52. Y.-C. Tung* and K. Kurabayashi, “Nanoimprinted Strain-Controlled Elastomeric Gratings for Optical Wavelength Tuning,” Applied Physics Letters, Vol. 86, Issue 16, pp. 161113 (3 pages), April 2005 (featured as the cover image). (also published in Virtual Journal of Nanoscale Science and Technology, Vol. 11, No. 16)
    [ DOI:10.1109/JMEMS.2005.844762 ]
  53. Y.-C. Tung, M. Zhang, C.-T. Lin, K. Kurabayashi, and S.J. Skerlos*, “PDMS-Based Opto-Fluidic Micro Flow Cytometer with Two-Color, Multi-Angle Fluorescence Detection Capability using PIN Photodiodes,” Sensors and Actuators B – Chemical, Vol. 98, pp. 356-367, March 2004.
    [ DOI:10.1016/j.snb.2003.10.010, ]
  54. D. Huh, Y.-C. Tung, H.-H. Wei, J.B. Grotberg, S.J. Skerlos, K. Kurabayashi, and S. Takayama*, “Use of Air-Liquid Two-Phase Flow in Hydrophobic Microfluidic Channels for Disposable Flow Cytometers,” Biomedical Microdevices, Vol. 4, No. 2, pp. 141-149, May 2002.
    [ DOI:10.1023/A:1014691416614 ]
  55. S.-H. Chang* and Y.-C. Tung, “Electro-Elastic Characteristics of Asymmetric Rectangular Piezoelectric Laminae,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 46, No. 4, pp. 950-960, July 1999.
    [ DOI:10.1109/58.775662. ]
  56. S.-H. Chang* and Y.-C. Tung, “A Novel Design of Piezo-Driven Dual-Dimension Optical Scanning Mechanism,” The Review of Scientific Instruments, Vol. 69, No. 9, pp. 3277-3282, September 1998.
    [ DOI:10.1063/1.1149092 ]